The purpose of the study was to investigate stress-related personality traits, hardiness, and burnout on job satisfaction in nurse. The study included 250 nurses working in 3 university hospitals in Seoul and Kyunggi provinces. The data were collected from 13, November, 2009 to 24th November, 2009. It was analyzed with descriptive statistics and Pearson correlation of SPSS and with multiple stepwise regression. The results are as follows. They were significant differences in stress resistant personality trait, hardiness, burnout, and job satisfaction by education, marital status, religion, position, field. There was found significant and positive correlation among stress resistant personality trait and job satisfaction; significant and negative correlation among stress resistant personality trait and burnout; significant and negative correlation among burnout and hardiness, job satisfaction. Regression analysis, burnout, hardiness, stress-related personality traits order influenced job satisfaction. Stress-related personality traits, hardiness, and burnout were significant predictors of job satisfaction. Stress-related personality traits, hardiness, and burnout is an important factor of job satisfaction in nurse, and significant correlations between their relationships. The results suggest that hospital and nursing managers must recognize these facts and provide various intervention to improving the job satisfaction in nurse. (Korean J Str Res 2011;19:79∼87)