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- Original Article 연자육의 항우울 효과에 대한 뇌부위별 신경전달물질의 변화
- 김지현*ㆍ이규섭†ㆍ정혜영†ㆍ심현수†ㆍ배현수‡ㆍ김경수†ㆍ심인섭†
- The Neurochemical Study on Antidepressant Effect of Nelumbinis Semen Extract
- Ji Hyun Kim*, Kyu-Sop Lee†, Hye-Young Joung†, Hyun Soo Shim†, Hyunsu Bae‡, Kyung Soo Kim†
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STRESS 2008;16(4):393-400
DOI: https://doi.org/
Published online: December 31, 2008
*가톨릭대학교 의과대학 면역생물학연구소, †가톨릭대학교 의과대학 통합의학교실, ‡경희대학교 한의과대학 생의학교실
*Research Institute of Immunobiology, Department of Biomedical Sciences, The Catholic University of Korea, †Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, ‡Department of Physiol
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Abstract
In the previous study, we examined that a variety of extracts of Nelumbinis semen (NS) have an antidepressant effect on the forced swimming test (FST) in the rat, which is widely used as a behavioral screening test for antidepressant activity of new compounds. Depression-like symptom in n-BuOH extract showed the strongest inhibitory effect on the immobility time and further fractionated n-BuOH with H2O and MeOH (3:7) fraction (NS37) was the most effective on the immobility time on FST. The purpose of the present study was to observe the neurochemical changes on the anti-depressant actions of unknown compounds in the NS37 extract by using HPLC coupled with electrochemical detection (ECD). The results showed that the NS37-10 (10 mg/kg) has a significant increase of dopamine in cortex, hypothalamus, and hippocampus and a significant decrease of dopamine turnover in hypothalamus and hippocampus. These neurochemical actions of NS37 extract could be responsible for the beneficial effect on depression. (Korean J Str Res 2008;16:393∼400)
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