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HOME > STRESS > Volume 21(2); 2013 > Article
Original Article
Association of AGT Polymorphisms with Benign Prostate Hyperplasia in Korean Population
Hosik Seok*, Young Ock Kim, Sang Hyub Lee, Koo Han Yoo, Byung-Cheol Lee§, Hye Sook Jeon*, Su Kang Kim*, Joo-Ho Chung*
STRESS 2013;21(2):151-157
DOI: https://doi.org/
Published online: June 30, 2013



*Kohwang Medical Research Institute and Department of Pharmacology, Kyung Hee University, Seoul, Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Department of Urology, Colle

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Most of aging-related disorders are related with stress responses in cellular level. In males after middle age, benign prostate hyperplasia (BPH) may cause severe stress by lower urinary tract symptoms. BPH is common androgenic disorder and family history is an etiological factor. As BPH is a multifactorial disease, many genes and cellular pathways may affect the development. Among them, Angiotensinogen (AGT) was regarded important in vascular diseases. AGT also may affect various diseases throughout whole body organs and polymorphisms of AGT may be associated with aging-related morbidities. AGT and stress genes related to AGT signaling may play a role in the pathophysiology of BPH. However, there was no study of BPH regarding the effect of AGT polymorphisms. In this study, we investigated the association of two AGT single nucleotide polymorphisms (SNPs) (rs699 and rs4762) to the development and clinical features of BPH. A total of 221 BPH subjects and 212 control subjects were analyzed. The BPH patient group was divided into two groups based on each of clinical features [prostate volume, peak urinary flow rate (Qmax), serum prostate specific antigen (PSA) level, and international prostate symptom scores (IPSS)] to analyze the effect of the SNPs on each of clinical parameters. In the result, a missense SNP rs699 was only associated to the development of BPH in the genotypes and allele frequencies (p<0.05). In conclusion, we suggest that a missense SNP rs699 of AGT may affect the susceptibility to BPH in the Korean population. (Korean J Str Res 2013;21: 0∼157)

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