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Original Article 트레드밀 운동이 외상성 뇌손상에 의하여 유발된 흰쥐의 단기기억 장애와 신경세포생성에 미치는 영향
김보균*ㆍ신말순*ㆍ조정완*ㆍ이희혁ㆍ김창주*
Treadmill Exercise Alleviates Traumatic Brain Injury-Induced Memory Impairment by Enhancing Cell Proliferation in the Hippocampus of Rats
Bo-Kyun Kim*, Mal-Soon Shin*, Jung-Wan Cho*, Hee-Hyuk Lee, Chang-Ju Kim*
STRESS 2013;21(2):141-149
DOI: https://doi.org/
Published online: June 30, 2013

*경희대학교 의과대학 생리학교실, 한남대학교 이과대학 생활체육학과



*Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Department of Sports Science, College of Nature Sciences, Han Nam University, Daejeon, Korea

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Traumatic brain injury (TBI) induces many neuropsychiatric disorders, and memory loss is the most frequent symptom of TBI. In the present study, we investigated the effects of treadmill exercise on the short-term memory in relation with cell proliferation in the hippocampus following TBI in rats. The animals were randomly divided into four groups (N=10 in each group): sham-operation group, sham-operation and treadmill exercise group, TBI-induction group, and TBI-induction and treadmill exercise group. TBI was induced by an electromagnetic-controlled cortical impact. The animals in the treadmill exercise group were forced to run on the treadmill machine for 30 min once daily, for ten consecutive days. Induction of TBI deteriorated short-term memory and inhibited cell proliferation with suppressing brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Treadmill exercise alleviated TBI-induced short-term memory impairment and also increased cell proliferation with enhancing BDNF expression in the hippocampus. The present results revealed that treadmill exercise overcame the TBI-induced memory impairment through enhancing cell proliferation in the hippocampus. Herein, we suggest that treadmill exercise may be used as the useful strategy for the functional recovery following traumatic brain damage. (Korean J Str Res 2013;21: 0∼149)

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