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- Original Article 카페인 투여 흰쥐의 뇌 부위별 GABA 함량 변화
- 오진경*ㆍ정은이†ㆍ심인섭†
- Changes of GABA Levels in Rat Brain Treated by Caffeine
- Jin-Kyung Oh*, Eun-Yee Jung†, In sop Shim†
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STRESS 2010;18(2):161-165
DOI: https://doi.org/
Published online: June 30, 2010
*가톨릭대학교 의과대학 통합의학교실, †경희대학교 침구경락과학연구센터
*Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, †Acupuncture & Meridian Science Research Center, Kyung Hee University, Seoul, Korea
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Abstract
Caffeine administration has been used to model sleep disruption. The purpose of this study was to examine the relation of caffeine with GABA (gamma amino butyric acid) levels in a translational caffeine-induced model of insomnia in rats. The change of GABA levels in caffeine-treated rat brain such as the cerebral cortex, hypothalamus, raphe nuclei (RN) andventral tegmental area (VTA) was investigated. GABA levels were significantly decreased with a time course by the administration of caffeine in the cerebral cortex and hypothalamus. There was a tendency that the GABA level in the RN, but not in the VTA was decreased. At high dose caffeine-treated rat, GABA levels were decreased in all the brain area. Especially, GABA levels were significantly decreased in the cerebral cortex and hypothalamus. These results suggest that the changes of GABA contents in caffeine-treated rat brain may be associated with many of the signs of insomnia or sleep disorders. (Korean J Str Res 2010;18:161∼165)
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