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Original Article
Stress-induced Neuroimmuno Alterations in the Rat
Hyun-ju Lee*, Kyung Soo Kim*, Insop Shim
STRESS 2010;18(2):81-86
DOI: https://doi.org/
Published online: June 30, 2010



*Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Acupunture Meridian Science Research Center, Kyunghee University Seoul, Korea

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Severe stress such as immobilization (IMO) affects the central nervous system, the endocrine system and the immune system that interact each other. IMO-induced responses are activation of hypothalamic-pituitary-adrenal (HPA) axis and production of inflammatory cytokine. The locus coeruleus (LC), which is known to play a role in modulating stress response, innervates the paraventricular neucleus (PVN) of the hypothalamus thereby activating HPA-axis. In this study, IMO-induced alterations of HPA-axis hormones and interleukin-4 (IL-4) were investigated. The final hormone of HPA-axis, corticosterone (CORT) was injected to clarify the interaction of the HPA-axis and IL-4 in the stress response. Single exposure of stress resulted in an increase of corticotrophin-releasing factor expression in the PVN, adrenocorticotropin hormone and CORT levels in the serum. Increased expressions of HPA-axis hormones in the acute stressed group were decreased in repeated stressed group. IL-4 level in the LC of the brain was decreased in both stressed group and repeated CORT injected group. These results suggest the possibility of stress-induced interplay of HPA-axis and IL-4 in the LC. (Korean J Str Res 2010;18:81∼86)

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