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- Original Article 스트레스 정도에 따른 혈중 인슐린 양 성장인자-1 농도의 차이
- 공미희*†ㆍ김광민‡ㆍ 박샛별‡ㆍ김범택‡ㆍ주남석‡
- Difference in Plasma Insulin-like Growth Factor-1 Concentration according to Degree of Stress
- Mi Hee Kong*†, Kwang Min Kim‡, Sat Byul Park‡, Bom Taeck Kim‡, Nam Seok Joo‡
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STRESS 2008;16(3):207-212
DOI: https://doi.org/
Published online: September 30, 2008
*제주대학교 의과대학 가정의학교실, †제주대학교 의과학연구소, ‡아주대학교 의과대학 가정의학교실
*Department of Family Medicine, Cheju National University, †Institute of Medical Science, Cheju National University, Jeju, ‡Department of Family Medicine and Community Health, Ajou University, College of Medicine, Suwon,
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Abstract
Purpose: Stress by activation the hypothalamic-pituiraty-adrenal axis causes the release cortisol. Increased cortisol secretion is associated with low levels of growth hormone concentrations. Insulin-like growth factor-1 (IGF-1) production is stimulated by growth hormone. We hypothesize that stress may be associated with IGF-1 levels. Methods: We assessed circulating levels of IGF-1 in 2,371 individuals (Men 1,460, Women 911) who coming at health promotion center. Stress score was measure by Modified-Korean BEPSI self reported questionnaire. Results: In young men, IGF-1 level of high stress group was significantly decreased than lower stress group. This significance was remained after multivariable adjusted. But, young women and elderly groups had not significant difference of IGF-1 level according to the low stress or high stress. Conclusion: The IGF-1 level of high stress group was decreased than low stress group. But, this significant difference was showed in only young men. (Korean J Str Res 2008;16:207∼211)
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