이화여자대학교 의과학연구소 비뇨기과학교실
Department of Urology, Medical Research Center, Ewha Womans University College of Medicine
This study was designed to examine the effect of stress on the pathophysiology of bladder stability via Rho-kinase that are required for muscle contraction and relaxation within the bladder. In addition, through animal model using metabolic cage, it was proven that a stressful environment can induce urinary incontinence. The results also showed that levels of ROKՁ all significantly increased with continued application of stress. In this study the control group placed under normal conditions and the test group under stressful conditions were monitored in Metabolic cages for 27 days. The frequency of urination increased significantly in the stress group and the amount of urine that decreased on the contrary showed symptoms of overactive bladder. This study, therefore, provides evidence which support the hypothesis that stress plays an important patho-physiological role in bladder overactivity. (Korean J Str Res 2006;14:211∼218)