Abstract

Pain is the most common chief complaint in any clinical setting and has been thought to be a simple sensory reponse from tissue damage. But recent have reveled that patients with minimal or no pathophysiology can show pain, especially chronic pain by a cognitive mechanisms, sensory function, and complex neurologic processing. Neuroanatomic structures make any stress initiate neurohumoral responses and a sickness response can come from these as a physiologic process. Pain is one of the protective mechanisms of sickness response, but chronic pain can develop if the sickness response persists without underlying harmful condition and thereaten biological integration. Pain is a complex sensory and cognitive consciousness and can be modified by memory which can bias the personal interation. Chronic pain is often associated with physical and psychological stress and cannot be diagnosed completely by a single physical or radiological findings. Thorough physical and psycological stress evaluation is required for the refractory chronic pain.

• Keywords: pain, chronic pain, stress, sickness response.