The purpose of this study was to identify the relationship among Fatigue, Perceived Stress, Symtoms of Stress, and Fatigue-Regulation Behavior of the Patient with Chronic Fatigue. Date were collected by questionnaires from 252 patient with chronic fatigue in General Hospital and Community in Seoul. The data were analyzed using descriptive statistics, pearson correlation coefficients, and stepwise multiple regression. Results were as follows: 1. The score of Fatigue showed significantly positive correlation with the score of Symptoms of Stress, Perceived Stress, and Fatigue-regulating behavior. 2. There was the highest correlation between emotion related to fatigue and symptoms of stress. This study suggest so that perceived stress, emotion related to fatigue, and symptoms of stress are significantly influencing factors on self-regulation behavior of the patients with chronic fatigue.