This study was performed to identify the mediating effect of alcohol expectancy and moderating effect of coping response on the relation between university students’ stress and drinking problem.

Data collected from 264 university students’ self-report questionnaire, including life daily stress, alcohol expectancy, coping response, drinking problem were analyzed.

The mediating effect of alcohol expectancy was significant (β=.26, p<.001). Although, the moderating effect of approach coping response was not significant, the moderating effect of avoidance coping response was significant (β=.12, p<.01).

These results suggest that treatment and intervention for drinking problems of university students’ must pay attention on alcohol expectancy and try to decrease the preference of avoidance coping response.