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Volume 15(2); June 2007
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Review Articles
Childhood Stress and Trauma
Boong-Nyun Kim
Korean J Str Res. 2007;15(2):67-71.   Published online June 30, 2007
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Coronary Artery Diseases and Psycho-social Environment
Jidong Sung
Korean J Str Res. 2007;15(2):73-77.   Published online June 30, 2007
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Treatment of Anxiety in Primary Care
Tae-Jin Park
Korean J Str Res. 2007;15(2):79-84.   Published online June 30, 2007
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Stress and Alopecia
Bark-Lynn Lew, Woo-Young Sim
Korean J Str Res. 2007;15(2):85-91.   Published online June 30, 2007
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Stress and Metabolic Syndrome
Do Hwan Yeo, Jong-Min Woo
Korean J Str Res. 2007;15(2):93-98.   Published online June 30, 2007
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Metabolic syndrome (MS) consists of multiple risk factors including elevated blood pressure, abdominal obesity, impaired glucose tolerance, and lipid abnormalities. The main characteristics of MS is insulin resistance and compensatory hyperinsulinemia introduced by abdominal obesity and physical inactivity and required to prevent decompensation of glucose homeostasis. If pancreatic insulin secretion fails to increase adequately, glucose intolerance and DM develops. MS is associated with cardiovascular and cerebrovascular disease which lead to chronic diseases and even to sudden death. Stress is one of contributing factors of MS. The individuals with stressors have unhealthy life styles including heavy drinking, excessive eating, and inactivation. Human body has compensatory mechanism in brain against stress. The main pathways are the hypothalamic-pituitaty-adrenal (HPA) axis and the sympathetic nervous system. The ACTH and cortisol hormone develop and worsen the abdominal obesity and insulin resistance. Chronic stress also stimulates growth hormone and glucagon hormone which aggravate glucose intolerance and result in DM. DM patients have difficulties in glucose control if they have stressors. The effective prevention and management of MS is necessary for modern civilians to be healthy. (Korean J Str Res 2007;15:93∼98)
Stress & Chronic Fatigue
Cheol Hwan Kim
Korean J Str Res. 2007;15(2):99-105.   Published online June 30, 2007
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Chronic fatigue (CF) is common symptom and reported in more than 10% of people seen in primary care and also seen in many physical and psychological disease. It is known that CF is related to acute or chronic stress response, although the mechanism is not clear. Many patients who have the stress-related diseases complaint disabilitating fatigue. And the most common risk factor of CF is stress and heavy overwork. Daytime stress cause the sleep disturbances (insomnia or sleep deprivation), and sleep abnormalities cause daytime fatigue and stress also. The relation of stress and CF is explained by biological model of chronic fatigue based on neuroendocrine axis [Hypothalamic-pituitary-adrenal axis and locus celuleus- norepinephrine (LC/NE)-autonomic system]. Chronic fatigue syndrome (CFS) is medically unexplained disorder that has multiple symptoms, especillay CF, cognitive function abnormality and sleep problems. It is well-known that CFS stress sensitive disorder. (Korean J Str Res 2007;15:99∼105)
Understanding of Adolescent Suicide
Sungpil Yook
Korean J Str Res. 2007;15(2):107-111.   Published online June 30, 2007
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Suicide is one of the big problems that we have to solve. But generally many people don't know the nature of adolescent suicide in Korea. Currently many people require mental health professionals to efforts to reduce or resolve the adolescent suicide. However, mental health professionals don't know how to manage this problem. Therefore, I will introduce the general facts of adolescent suicide and talk about the characteristic of adolescent suicide, additionally treatment approaches. (Korean J Str Res 2007;15:107∼111)
Develop the Integrated Stress Management Program for Elderly
Joohyun Kim
Korean J Str Res. 2007;15(2):113-120.   Published online June 30, 2007
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Animal Model of Depression: Past and Recent Development
Kyu-sop Lee, Kwang-Ho Pyun, Insop Shim
Korean J Str Res. 2007;15(2):121-126.   Published online June 30, 2007
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Depression is one of the most prevalent mood disorders that is characterized by a devastation, low mood, languor, inactivity and anhedonia. Until recently, many animal models of depression have been suggested on the basis of theory of depression. Most of animal models can be classified with stress, pharmacological and genetic models. To develop animal models of depression is very important for discovery and development of effective anti-depressants. This article focuses on stress and genetic animal models in depression. The first part of article describes traditional stress models: learned helplessness, forced swimming test, chronic mild stress and maternal separation. In the second part, it is known that genetic factors play a role in etiology of depression, and several genetic models have been introduced: Twik-1-related K+ channel, prostate apoptosis response 4, P11 gene. Since these models are now utilized to examine the etiology and pathophysiology of depression as well as an application of therapeutic medications, an availability of the reliable and valid animal models is critical in preclincial and clinical research of the depression. (Korean J Str Res 2007;15:121∼126)

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