This study aims to identify factors influencing burnout in nurses during COVID-19 disaster situations.

The research subjects were 131 nurses who had the experience of nursing patients during the COVID-19 pandemic, and were selected through convenience sampling. The collected data were subjected to percentage, mean and standard deviation, t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression analysis using the SPSS version 24.0 program.

Burnout in nurses showed a statistically significant correlation with anxiety, PTSD, and depression. It was also confirmed that nurses’ depression and shift work were important factors that had significant effects on burnout.

In preparation for new infectious diseases that are expected to become more frequent in the future, a policy to supply nursing manpower and prevent burnout is necessary. In addition, it is necessary to introduce various work systems and develop and disseminate intervention programs for depression and burnout.