This study examined 168 family care workers who work in the ChungnamㆍChungbuk Province about how role stress affects to depression, and verified moderating effects of family strength in this process. The results were as follows: First, it was found that role conflict of role stress was more than average level, and role overload of role stress was somewhat lower than average level. Family strength was found to be lower than average level, and depression was found to be higher than average level. Second, influential factors of depression were role overload, family strength, health status, and role conflict. Third, role overload was found to have moderating effects on the relationship between role stress and depression. Based on such empirical analysis results, this study suggested comprehensive working strategies to improve family strength and to prevent depression of family care workers.